Alterations in Alveolar Epithelium Differentiation and Vasculogenesis in Lungs of Lif/Igf-i Double Deficient Embryos.
From: Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas/Universidad de Salamanca, Salamanca, Spain.
Developmental dynamics : an official publication of the American Association of Anatomists
- Publish Date: Aug 2006
- ISSN: 1058-8388
- Volume: 235
- Issue: 8
- Pages: 2040-50
- Medium: Print
- Language: English
- Citation (JAMA): Moreno-Barriuso Nuria, López-Malpartida Ana V, de Pablo Flora, et al. Alterations in Alveolar Epithelium Differentiation and Vasculogenesis in Lungs of Lif/Igf-i Double Deficient Embryos.. Dev. Dyn. Aug 2006;235:2040-50
Abstract
Previous studies on double deficient mice for leukemia inhibitory factor (LIF) and insulin-like growth factor I (IGF-I) reported that they died of respiratory failure, with abnormal lung histology and altered expression of pulmonary markers. Here we analyzed prenatal Lif/Igf-I double mutant mouse embryos to characterize LIF and IGF-I cooperative roles in distal lung epithelium and vascular maturation. Lungs of IGF-I-deficient embryos displayed a higher proportion of type II pneumocytes, less differentiated type I pneumocytes, and failure in alveolar capillary remodeling compared to wild type and LIF-deficient mice. Lif/Igf-I double knockout lungs showed aggravated pulmonary hypoplasia, lower airway volume, increased proliferation, and elevated levels of ERK1/2 activation. In addition, their alveoli were collapsed and lined by type II cells. The differentiation of type I cells barely occurred and capillaries remained in the abundant mesenchyme. These results indicate that LIF collaborates with IGF-I in lung alveolar epithelium and vascular maturation.
Mesh Headings (Keywords): Animals, Biological Markers, Cell Differentiation, Cell Proliferation, Epithelium, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Developmental, Insulin-Like Growth Factor I, Interleukin-6, Leukemia Inhibitory Factor, Lung, Mice, Phosphorylation, Proliferating Cell Nuclear Antigen, RNA, Messenger
Check for Full Text / PubMed Unique Identifier (PMID): 16691571
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