Influence of Local Recurrence on Survival in Patients with Extremity Osteosarcoma Treated with Neoadjuvant Chemotherapy: the Experience of a Single Institution with 44 Patients.
From: Division of Chemotherapy, Institute Ortopedico Rizzoli, Bologna, Italy. gaetano.bacci@ior.it
Cancer
- Publish Date: Jun 2006
- ISSN: 0008-543X
- Volume: 106
- Issue: 12
- Pages: 2701-6
- Medium: Print
- Language: English
- Citation (JAMA): Bacci Gaetano, Longhi Alessandra, Cesari Marilena, et al. Influence of Local Recurrence on Survival in Patients with Extremity Osteosarcoma Treated with Neoadjuvant Chemotherapy: the Experience of a Single Institution with 44 Patients.. Cancer Jun 2006;106:2701-6
Abstract
BACKGROUND: Risk factors for local recurrence (LR) after osteosarcoma, such as surgical margins and histologic response to preoperative treatment, have been well documented, whereas the outcome for patients who locally recur has not been well established yet. METHODS: Retrospective analysis of the management and outcome of 44 patients who developed LR after treatment of osteosarcoma of the extremities with neoadjuvant chemotherapy was performed in a single institution between 1983 and 1999. RESULTS: In 24 patients (54.5%), LR was the first sign of recurrence; in 8 patients (18.2%) LR followed systemic recurrence and in 12 patients (27.3%), the 2 events, local and systemic recurrence, were concurrent. Of the 44 patients, 26 with local recurrences were free of disease, but only 5 were long-term event-free survivors, and 39 patients developed further recurrences: 37 died of the tumor and 2 were alive with uncontrolled disease at the time of last follow-up. The 5-year disease-free survival rate after the last recurrence was 15.9%; it was 25.9% for patients who achieved remission and 0% for the others. The only prognostic factor identified for post-LR disease-free survival was the presence of systemic recurrence at the time of diagnosis of LR or before (5-year postrecurrence event-free survival rate of 29.1% for patients without metastases at the time of local recurrence vs. 0% for those with metastases; P = .02). CONCLUSIONS: These results confirm that patients with osteosarcoma of the extremities who develop LR are at a very significantly high risk of developing metastatic disease and dying of the tumor.
Mesh Headings (Keywords): Adolescent, Adult, Bone Neoplasms, Child, Child, Preschool, Disease-Free Survival, Female, Humans, Male, Neoadjuvant Therapy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Osteosarcoma, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Time Factors, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 16691623
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.