Reelin is Transiently Expressed in the Peripheral Nerve During Development and is Upregulated Following Nerve Crush.
From: Laboratorio di Neuroscienze dello Sviluppo, Università Campus Bio-Medico, 00155 Roma, Italy. R.Panteri@unicampus.it
Molecular and cellular neurosciences
- Publish Date:
- ISSN: 1044-7431
- Volume: 32
- Issue: 1-2
- Pages: 133-42
- Medium: Print
- Language: English
- Citation (JAMA): Panteri Roger, Mey Jörg, Zhelyaznik Nina, et al. Reelin is Transiently Expressed in the Peripheral Nerve During Development and is Upregulated Following Nerve Crush.. Mol. Cell. Neurosci. ;32:133-42
Abstract
Reelin is an extracellular matrix protein which is critical for the positioning of migrating post-mitotic neurons and the laminar organization of several brain structures during development. We investigated the expression and localization of Reelin in the rodent peripheral nerve during postnatal development and following crush injury in the adult stage. As shown with Western blotting, immunocytochemistry and RT-PCR, Schwann cells in the developing peripheral nerve and in primary cultures from neonatal nerves produce and secrete Reelin. While Reelin levels are downregulated in adult stages, they are again induced following sciatic nerve injury. A morphometric analysis of sciatic nerve sections of reeler mice suggests that Reelin is not essential for axonal ensheathment by Schwann cells, however, it influences the caliber of myelinated axons and the absolute number of fibers per unit area. This indicates that Reelin may play a role in peripheral nervous system development and repair by regulating Schwann cell-axon interactions.
Mesh Headings (Keywords): Animals, Animals, Newborn, Axons, Cell Adhesion Molecules, Neuronal, Cell Communication, Cells, Cultured, Disease Models, Animal, Extracellular Matrix Proteins, Female, Gene Expression Regulation, Developmental, Male, Mice, Mice, Neurologic Mutants, Myelin Basic Proteins, Myelin Sheath, Nerve Regeneration, Nerve Tissue Proteins, Peripheral Nerves, RNA, Messenger, Schwann Cells, Sciatic Neuropathy, Serine Endopeptidases, Up-Regulation
Check for Full Text / PubMed Unique Identifier (PMID): 16697663
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