Ischemia-induced Increase in Rgs7 Mrna Expression in Gerbil Hippocampus.
From: Department of Biochemistry, M743 Medical Sciences Bldg, University of Missouri-Columbia, 65212, USA.
Neuroscience letters
- Publish Date: Jul 2006
- ISSN: 0304-3940
- Volume: 403
- Issue: 1-2
- Pages: 157-61
- Medium: Print
- Language: English
- Citation (JAMA): Shelat Phullara B, Coulibaly Aminata P, Wang Qun, et al. Ischemia-induced Increase in Rgs7 Mrna Expression in Gerbil Hippocampus.. Neurosci. Lett. Jul 2006;403:157-61
Abstract
The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.
Mesh Headings (Keywords): Animals, Brain Ischemia, Gerbillinae, Hippocampus, Male, RGS Proteins, RNA, Messenger
Check for Full Text / PubMed Unique Identifier (PMID): 16698180
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