Transspecies Transmission of the Endogenous Koala Retrovirus.
From: Robert Koch Institute, Nordufer 20, D-13353 Berlin, Germany.
Journal of virology
- Publish Date: Jun 2006
- ISSN: 0022-538X
- Volume: 80
- Issue: 11
- Pages: 5651-4
- Medium: Print
- Language: English
- Citation (JAMA): Fiebig Uwe, Hartmann Manuel Garcia, Bannert Norbert, et al. Transspecies Transmission of the Endogenous Koala Retrovirus.. J. Virol. Jun 2006;80:5651-4
Abstract
The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods for virus detection. The KoRV transmembrane envelope protein (p15E) was cloned and expressed, and p15E-specific neutralizing antibodies able to prevent virus infection in vitro were developed. Finally, evidence for immunosuppressive properties of the KoRV was obtained.
Mesh Headings (Keywords): Animals, Cell Line, Disease Transmission, Endogenous Retroviruses, Gammaretrovirus, Humans, Molecular Sequence Data, Phascolarctidae, Rats, Retroviridae Infections
Check for Full Text / PubMed Unique Identifier (PMID): 16699047
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