Improvement of Diabetes, Obesity and Hypertension in Type 2 Diabetic Kkay Mice by Bis(Allixinato)oxovanadium(Iv) Complex.
From: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
Biochemical and biophysical research communications
- Publish Date: Jul 2006
- ISSN: 0006-291X
- Volume: 345
- Issue: 3
- Pages: 945-50
- Medium: Print
- Language: English
- Citation (JAMA): Adachi Yusuke, Yoshikawa Yutaka, Yoshida Jiro, et al. Improvement of Diabetes, Obesity and Hypertension in Type 2 Diabetic Kkay Mice by Bis(Allixinato)oxovanadium(Iv) Complex.. Biochem. Biophys. Res. Commun. Jul 2006;345:945-50
Abstract
Previously, we found that bis(allixinato)oxovanadium(IV) (VO(alx)(2)) exhibits a potent hypoglycemic activity in type 1-like diabetic mice. Since the enhancement of insulin sensitivity is involved in one of the mechanisms by which vanadium exerts its anti-diabetic effects, VO(alx)(2) was further tested in type 2 diabetes with low insulin sensitivity. The effect of oral administration of VO(alx)(2) was examined in obesity-linked type 2 diabetic KKA(y) mice. Treatment of VO(alx)(2) for 4 weeks normalized hyperglycemia, glucose intolerance, hyperinsulinemia, hypercholesterolemia and hypertension in KKA(y) mice; however, it had no effect on hypoadiponectinemia. VO(alx)(2) also improved hyperleptinemia, following attenuation of obesity in KKA(y) mice. This is the first example in which a vanadium compound improved leptin resistance in type 2 diabetes by oral administration. On the basis of these results, VO(alx)(2) is proposed to enhance not only insulin sensitivity but also leptin sensitivity, which in turn improves diabetes, obesity and hypertension in an obesity-linked type 2 diabetic animal.
Mesh Headings (Keywords): Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Hypertension, Insulin Resistance, Leptin, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Chemical, Obesity, Organometallic Compounds, Tissue Distribution
Check for Full Text / PubMed Unique Identifier (PMID): 16707105
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