Suit, Secretory Units of Islets in Transplantation: An Index for Therapeutic Management of Islet Transplanted Patients and Its Application to Type 2 Diabetes.
From: Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606 8507, Japan. yamada@metab.kuhp.kyoto-u.ac.jp
Diabetes research and clinical practice
- Publish Date: Dec 2006
- ISSN: 0168-8227
- Volume: 74
- Issue: 3
- Pages: 222-6
- Medium: Print
- Language: English
- Citation (JAMA): Yamada Yuichiro, Fukuda Kazuhito, Fujimoto Shimpei, et al. Suit, Secretory Units of Islets in Transplantation: An Index for Therapeutic Management of Islet Transplanted Patients and Its Application to Type 2 Diabetes.. Diabetes Res. Clin. Pract. Dec 2006;74:222-6
Abstract
Evaluation of a patient’s pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of beta-cell function by the formula: 250 x F-CPR/(F-BG-3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R2 = 0.68, P < 0.05) but also in type 2 patients (R2 = 0.34, P < 0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic beta-cell function, the formula may be a useful tool in clinical management of diabetes.
Mesh Headings (Keywords): Blood Glucose, Diabetes Mellitus, Type 2, Humans, Insulin, Islets of Langerhans, Islets of Langerhans Transplantation
Check for Full Text / PubMed Unique Identifier (PMID): 16707190
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