5-ht Modulation of Identified Segmental Premotor Interneurons in the Lamprey Spinal Cord.
From: Department of Neuroscience, the Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden.
Journal of neurophysiology
- Publish Date: Aug 2006
- ISSN: 0022-3077
- Volume: 96
- Issue: 2
- Pages: 931-5
- Medium: Print
- Language: English
- Citation (JAMA): Biró Zoltán, Hill Russell H, Grillner Sten, et al. 5-ht Modulation of Identified Segmental Premotor Interneurons in the Lamprey Spinal Cord.. J. Neurophysiol. Aug 2006;96:931-5
Abstract
Ipsilaterally projecting spinal excitatory interneurons (EINs) generate the hemisegmental rhythmic locomotor activity in lamprey, while the commissural interneurons ensure proper left-right alternation. 5-HT is a potent modulator of the locomotor rhythm and is endogenously released from the spinal cord during fictive locomotion. The effect of 5-HT was investigated for three segmental premotor interneuron types: EINs, commissural excitatory and commissural inhibitory interneurons. All three types of interneurons produced chemical postsynaptic potentials in motoneurons, but only those from EINs had an electrical component. The effect of 5-HT was studied on the slow afterhyperpolarization, involved in spike frequency regulation, and on the segmental synaptic transmission to motoneurons. 5-HT induced a reduction in the slow afterhyperpolarization and a depression of synaptic transmission in all three types of segmental interneurons. Thus 5-HT is a very potent modulator of membrane properties and synaptic transmission of last-order segmental premotor interneurons. Such modulation of locomotor network interneurons can partially account for the observed effects of 5-HT on the swimming pattern in lamprey.
Mesh Headings (Keywords): Action Potentials, Animals, Electrophysiology, Evoked Potentials, Motor, Histocytochemistry, Interneurons, Lampreys, Motor Neurons, Serotonin, Spinal Cord, Synaptic Transmission
Check for Full Text / PubMed Unique Identifier (PMID): 16707720
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