Allometric Scaling of Wall Shear Stress from Mice to Humans: Quantification Using Cine Phase-contrast Mri and Computational Fluid Dynamics.
From: Clark Center, E350, 318 Campus Dr., Stanford, CA 94305-5431, USA.
American journal of physiology. Heart and circulatory physiology
- Publish Date: Oct 2006
- ISSN: 0363-6135
- Volume: 291
- Issue: 4
- Pages: H1700-8
- Medium: Print
- Language: English
- Citation (JAMA): Greve Joan M, Les Andrea S, Tang Beverly T, et al. Allometric Scaling of Wall Shear Stress from Mice to Humans: Quantification Using Cine Phase-contrast Mri and Computational Fluid Dynamics.. Am. J. Physiol. Heart Circ. Physiol. Oct 2006;291:H1700-8
Abstract
Allometric scaling laws relate structure or function between species of vastly different sizes. They have rarely been derived for hemodynamic parameters known to affect the cardiovascular system, e.g., wall shear stress (WSS). This work describes noninvasive methods to quantify and determine a scaling law for WSS. Geometry and blood flow velocities in the infrarenal aorta of mice and rats under isoflurane anesthesia were quantified using two-dimensional magnetic resonance angiography and phase-contrast magnetic resonance imaging at 4.7 tesla. Three-dimensional models constructed from anatomic data were discretized and used for computational fluid dynamic simulations using phase-contrast velocity imaging data as inlet boundary conditions. WSS was calculated along the infrarenal aorta and compared between species to formulate an allometric equation for WSS. Mean WSS along the infrarenal aorta was significantly greater in mice and rats compared with humans (87.6, 70.5, and 4.8 dyn/cm(2), P < 0.01), and a scaling exponent of -0.38 (R(2) = 0.92) was determined. Manipulation of the murine genome has made small animal models standard surrogates for better understanding the healthy and diseased human cardiovascular system. It has therefore become increasingly important to understand how results scale from mouse to human. This noninvasive methodology provides the opportunity to serially quantify changes in WSS during disease progression and/or therapeutic intervention.
Mesh Headings (Keywords): Animals, Aorta, Biomechanics, Blood Flow Velocity, Body Mass Index, Body Size, Cardiovascular Diseases, Cardiovascular Physiology, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Cine, Male, Mice, Mice, Inbred C57BL, Models, Theoretical, Rats, Rats, Sprague-Dawley, Species Specificity
Check for Full Text / PubMed Unique Identifier (PMID): 16714362
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