Chop is Involved in Neuronal Apoptosis Induced by Neurotrophic Factor Deprivation.
From: Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Japan.
FEBS letters
- Publish Date: Jun 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 14
- Pages: 3462-8
- Medium: Print
- Language: English
- Citation (JAMA): Tajiri Seiji, Yano Shigetoshi, Morioka Motohiro, et al. Chop is Involved in Neuronal Apoptosis Induced by Neurotrophic Factor Deprivation.. FEBS Lett. Jun 2006;580:3462-8
Abstract
Neurotrophic factors are essential for the survival of neurons. We found that the endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway to be activated during neurotrophic factor deprivation-induced apoptosis in PC12 neuronal cells and in primary cultured neurons, and this apoptosis was suppressed in the neurons from chop(-/-) mice. In addition, we found that CHOP is expressed in the subventricular zone (SVZ) and striatum of the young adult mouse brain. The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain.
Mesh Headings (Keywords): Animals, Apoptosis, Base Sequence, Cells, Cultured, Corpus Striatum, DNA Primers, Immunohistochemistry, In Situ Nick-End Labeling, Mice, Nerve Growth Factors, Neurons, PC12 Cells, Rats, Reverse Transcriptase Polymerase Chain Reaction, Transcription Factor CHOP
Check for Full Text / PubMed Unique Identifier (PMID): 16716308
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