Increased Interleukin-6 After Cardiac Surgery Predicts Infection.
From: Department of Anesthesiology and Intensive Care Medicine, Charité University Medicine Berlin, Charité Campus Mitte, Schumannstr. 20/21, 10117 Berlin, Germany. michael.sander@charite.de
Anesthesia and analgesia
- Publish Date: Jun 2006
- ISSN: 1526-7598
- Volume: 102
- Issue: 6
- Pages: 1623-9
- Medium: Internet
- Language: English
- Citation (JAMA): Sander Michael, von Heymann Christian, von Dossow Vera, et al. Increased Interleukin-6 After Cardiac Surgery Predicts Infection.. Anesth. Analg. Jun 2006;102:1623-9
Abstract
Early diagnosis and treatment of infection after cardiac surgery with cardiopulmonary bypass (CPB) improves outcome. Conventional laboratory tests, such as C-reactive protein and white blood cell count can not distinguish patients with early infection from those with systemic inflammatory response syndrome but without infection. After CPB, there is a systemic release of proinflammatory and antiinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and IL-10. We investigated the predictive ability of these variables for infection after cardiac surgery. Forty-six patients with impaired left ventricular ejection fraction (<60%), scheduled for cardiac surgery, were included. Plasma samples were drawn 1 day before and immediately before surgery, on admission to the intensive care unit, and on days 1, 3, and 7 after surgery. Infection was identified according to the criteria of the Centers for Disease Control and Prevention. After surgery 13 patients developed an infection. In patients with infection, confirmed a median of 4 days after surgery, all measurements of IL-6, and IL-10 on postoperative day 3 were significantly increased. Tumor necrosis factor-alpha, leukocytes, and C-reactive protein were not increased in these patients. Immediately after surgery blood glucose was significantly increased in patients with infection. Increased IL-6 after CPB is predictive of infection after cardiac surgery in patients with impaired left ventricular function.
Mesh Headings (Keywords): Aged, Biological Markers, Blood Glucose, Cardiac Surgical Procedures, Female, Humans, Infection, Interleukin-10, Interleukin-6, Male, Middle Aged, Postoperative Complications, Predictive Value of Tests, Tumor Necrosis Factor-alpha
Check for Full Text / PubMed Unique Identifier (PMID): 16717298
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