Gamma-aminobutyric Acid Secreted from Islet Beta-cells Modulates Exocrine Secretion in Rat Pancreas.
From: Department of MedicoLife Science, Youngdong University, Chungbuk, Korea.
World journal of gastroenterology : WJG
- Publish Date: May 2006
- ISSN: 1007-9327
- Volume: 12
- Issue: 19
- Pages: 3026-30
- Medium: Print
- Language: English
- Citation (JAMA): Park Yong-Deuk, Cui Zheng-Yun, Wu Guang, et al. Gamma-aminobutyric Acid Secreted from Islet Beta-cells Modulates Exocrine Secretion in Rat Pancreas.. World J. Gastroenterol. May 2006;12:3026-30
Abstract
AIM: To investigate the role of endogenous gamma-amino-butyric acid (GABA) in pancreatic exocrine secretion. METHODS: The isolated, vascularly perfused rat pancreas was employed in this study to eliminate the possible influences of extrinsic nerves and hormones. Cholecystokinin (CCK; 10 pmol/L) was intra-arterially given to stimulate exocrine secretion of the pancreas. RESULTS: Glutamine, a major precursor of GABA, which was given intra-arterially at concentrations of 1, 4 and 10 mmol/L, dose-dependently elevated the CCK-stimulated secretions of fluid and amylase in the normal pancreas. Bicuculline (10 micromol/L), a GABA(A) receptor antagonist, blocked the enhancing effect of glutamine (4 mmol/L) on the CCK-stimulated exocrine secretions. Glutamine, at concentrations of 1, 4 and 10 mmol/L, dose-dependently increased the GABA concentration in portal effluent of the normal pancreas. The effects of glutamine on the CCK-stimulated exocrine secretion as well as the GABA secretion were markedly reduced in the streptozotocin-treated pancreas. CONCLUSION: GABA could be secreted from beta-cells into the islet-acinar portal system after administration of glutainine, and could enhance the CCK-stimulated exocrine secretion through GABA(A) receptors. Thus, GABA in islet beta-cells is a hormone modulating pancreatic exocrine secretion.
Mesh Headings (Keywords): Animals, Bicuculline, Cholecystokinin, Dose-Response Relationship, Drug, GABA Antagonists, Glutamine, Insulin-Secreting Cells, Male, Pancreas, Exocrine, Rats, Rats, Sprague-Dawley, Receptors, GABA-A, gamma-Aminobutyric Acid
Check for Full Text / PubMed Unique Identifier (PMID): 16718782
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