New Potent P-glycoprotein Inhibitors Carrying a Polycyclic Scaffold.
From: Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy. alessandra.bisi@unibo.it
Journal of medicinal chemistry
- Publish Date: Jun 2006
- ISSN: 0022-2623
- Volume: 49
- Issue: 11
- Pages: 3049-51
- Medium: Print
- Language: English
- Citation (JAMA): Bisi Alessandra, Gobbi Silvia, Rampa Angela, et al. New Potent P-glycoprotein Inhibitors Carrying a Polycyclic Scaffold.. J. Med. Chem. Jun 2006;49:3049-51
Abstract
New pentacyclic inhibitors of the P-glycoprotein carrying nitrogen-containing alkyl chains were synthesized and evaluated for MDR reverting activity on mouse lymphoma cells infected with pHa MDR1/A retrovirus. The activity of the compounds proved to be up to 5-fold higher than verapamil, used as reference compound.
Mesh Headings (Keywords): Animals, Antineoplastic Agents, Cell Line, Transformed, Cell Line, Tumor, Drug Resistance, Neoplasm, Genes, MDR, Heterocyclic Compounds with 4 or More Rings, Mice, P-Glycoprotein, Retroviridae
Check for Full Text / PubMed Unique Identifier (PMID): 16722621
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