Progestin-based Contraceptive Suppresses Cellular Immune Responses in Shiv-infected Rhesus Macaques.
From: Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA.
Virology
- Publish Date: Aug 2006
- ISSN: 0042-6822
- Volume: 352
- Issue: 1
- Pages: 169-77
- Medium: Print
- Language: English
- Citation (JAMA): Trunova Nataliya, Tsai Lily, Tung Stephanie, et al. Progestin-based Contraceptive Suppresses Cellular Immune Responses in Shiv-infected Rhesus Macaques.. Virology Aug 2006;352:169-77
Abstract
Nine rhesus macaques in groups of three received a single dose of the injectable progestin-based contraceptive Depo-Provera 5 weeks prior to challenge intravaginally with varying doses of a mixture of the pathogenic CXCR4 (X4)-SHIV(SF33A) and CCR5 (R5)-SHIV(SF162P3) isolates. As controls, seven Depo-naive animals were inoculated once with a high-dose of the mixed inoculum. Irrespective of inoculum dose, acute viremia was higher in the Depo-treated than in the Depo-naive animals. Further, genetic complexity of the replicating virus was greater and replication of the X4 virus was favored in dually infected animals treated with Depo-Provera. Analysis of cellular immune responses revealed slower response rates in virus-specific IFN-gamma production to SIV Gag in the Depo-treated macaques. The immunosuppressive effect of Depo-Provera on mounting an antiviral cellular immune response may account for the increase viral burden and diversity, and the predominance of X4 virus replication in SHIV infected macaques that were administered the progestin-based contraceptive.
Mesh Headings (Keywords): Animals, Contraceptive Agents, Female, Disease Susceptibility, Female, HIV Infections, HIV-1, Humans, Interferon Type II, Lymphocyte Activation, Macaca mulatta, Medroxyprogesterone 17-Acetate, Progestins, Simian Acquired Immunodeficiency Syndrome, Simian immunodeficiency virus, T-Lymphocytes, Viral Load, Virus Replication
Check for Full Text / PubMed Unique Identifier (PMID): 16730772
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