Cue-induced Cocaine Seeking and Relapse Are Reduced by Disruption of Drug Memory Reconsolidation.
From: Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom. jlcl2@cam.ac.uk
The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publish Date: May 2006
- ISSN: 1529-2401
- Volume: 26
- Issue: 22
- Pages: 5881-7
- Medium: Internet
- Language: English
- Citation (JAMA): Lee Jonathan L C, Milton Amy L, Everitt Barry J, et al. Cue-induced Cocaine Seeking and Relapse Are Reduced by Disruption of Drug Memory Reconsolidation.. J. Neurosci. May 2006;26:5881-7
Abstract
Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction. Here we show that blockade of drug memory reconsolidation, through infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impaired subsequently cue-maintained cocaine seeking under a second-order schedule of reinforcement and abolished cue-induced reinstatement of and relapse to cocaine seeking. This reduction in relapse after disrupted memory reconsolidation was not only seen after several hundred pairings of the stimulus with self-administered cocaine, but older, as well as recent, memories were also disrupted. Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction.
Mesh Headings (Keywords): Animals, Cocaine, Cocaine-Related Disorders, Conditioning (Psychology), Cues, Exploratory Behavior, Memory, Memory Disorders, Mutation, Missense, Rats, Self Administration
Check for Full Text / PubMed Unique Identifier (PMID): 16738229
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