Vibrissa-signaled Eyeblink Conditioning Induces Somatosensory Cortical Plasticity.
From: Department of Physiology, Institute for Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. r-galvez@northwestern.edu
The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publish Date: May 2006
- ISSN: 1529-2401
- Volume: 26
- Issue: 22
- Pages: 6062-8
- Medium: Internet
- Language: English
- Citation (JAMA): Galvez Roberto, Weiss Craig, Weible Aldis P, et al. Vibrissa-signaled Eyeblink Conditioning Induces Somatosensory Cortical Plasticity.. J. Neurosci. May 2006;26:6062-8
Abstract
Whisker deflection conditioned stimuli (CS) were demonstrated to activate physiologically and anatomically defined barrels in the contralateral somatosensory cortex and to support trace-eyeblink conditioned responses when paired with corneal airpuff unconditioned stimuli in rabbits. Analysis of cytochrome-oxidase-stained somatosensory whisker-associated cortical barrels revealed a row-specific expansion of the conditioned compared with the nontrained hemisphere. This expansion was not evident in pseudo-conditioned rabbits, suggesting that this expansion of conditioned cortical barrels in response to a hippocampal- and forebrain-dependent learning task (trace conditioning) is associative rather than activity dependent. Using whisker stimulation as a CS in the well studied eyeblink conditioning paradigm will facilitate characterizing sensory cortical involvement in controlling and modulating an associatively learned response at the neural systems and cellular level.
Mesh Headings (Keywords): Animals, Blinking, Cerebral Cortex, Conditioning (Psychology), Electron Transport Complex IV, Electrophysiology, Female, Functional Laterality, Models, Animal, Neuronal Plasticity, Physical Stimulation, Rabbits, Somatosensory Cortex, Stereotaxic Techniques, Vibrissae
Check for Full Text / PubMed Unique Identifier (PMID): 16738249
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