Oxidative Damage of Periodontal Tissue in the Rat Periodontitis Model: Effects of a High-cholesterol Diet.
From: Department of Oral Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
FEBS letters
- Publish Date: Jun 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 15
- Pages: 3601-4
- Medium: Print
- Language: English
- Citation (JAMA): Tomofuji Takaaki, Azuma Tetsuji, Kusano Hiroki, et al. Oxidative Damage of Periodontal Tissue in the Rat Periodontitis Model: Effects of a High-cholesterol Diet.. FEBS Lett. Jun 2006;580:3601-4
Abstract
Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.
Mesh Headings (Keywords): Animal Feed, Animals, Cholesterol, Deoxyguanosine, Disease Models, Animal, Fibroblasts, Interleukin-1, Male, Mitochondria, Oxidation-Reduction, Periodontitis, Rats, Rats, Wistar, Triglycerides, Tumor Necrosis Factor-alpha
Check for Full Text / PubMed Unique Identifier (PMID): 16750199
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