Microvascular Function, Metabolic Syndrome, and Novel Risk Factor Status in Women with Cardiac Syndrome X.
From: The Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom. stjadhav@bigfoot.com
The American journal of cardiology
- Publish Date: Jun 2006
- ISSN: 0002-9149
- Volume: 97
- Issue: 12
- Pages: 1727-31
- Medium: Print
- Language: English
- Citation (JAMA): Jadhav Sachin T, Ferrell William R, Petrie John R, et al. Microvascular Function, Metabolic Syndrome, and Novel Risk Factor Status in Women with Cardiac Syndrome X.. Am. J. Cardiol. Jun 2006;97:1727-31
Abstract
To characterize microvascular function, candidate risk pathways, and metabolic syndrome prevalence in women with cardiac syndrome X, 52 nondiabetic women with angiographically normal epicardial arteries but >1 mm of planar ST depression during exercise testing (patients) and 24 healthy controls of similar age were recruited. In addition to fasting blood samples and anthropometric measurements, forearm cutaneous microvascular function after iontophoresis of acetylcholine and sodium nitroprusside was assessed by laser Doppler imaging. Despite body mass index correction and a larger proportion on statin therapy, patients had high levels of insulin (p=0.016), triglycerides (p=0.018), intercellular adhesion molecule-1 (p=0.021), von Willebrand factor (p=0.005), and leptin (p=0.005) and lower levels of high-density lipoprotein cholesterol (p=0.042) compared with controls. Consistent with these data, 30% of patients but only 8% of controls fulfilled criteria for the metabolic syndrome as defined by the National Cholesterol Education Program (p=0.015). Endothelium-dependent and -independent microvascular functions were markedly impaired in patients (p<0.001), and the odds ratio for cardiac syndrome X was 7.38 (95% confidence interval 2.2 to 24.7) if the acetylcholine response was <8,710 flux units. In conclusion, women with cardiac syndrome X more commonly have metabolic syndrome and related adiposity, metabolic, and inflammatory derangements. They also have significantly impaired skin microvascular function as assessed by laser Doppler imaging, consistent with generalized vascular dysfunction, a finding with potential diagnostic implications.
Mesh Headings (Keywords): Acetylcholine, Biological Markers, Blood Pressure, Body Mass Index, Case-Control Studies, Cholesterol, HDL, Exercise Test, Female, Humans, Insulin, Intercellular Adhesion Molecule-1, Iontophoresis, Laser-Doppler Flowmetry, Leptin, Metabolic Syndrome X, Microcirculation, Microvascular Angina, Middle Aged, ROC Curve, Risk Factors, Skin, Triglycerides, Vasodilator Agents, von Willebrand Factor
Check for Full Text / PubMed Unique Identifier (PMID): 16765122
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.