Identification of Genes That Express in Response to Light Exposure and Express Rhythmically in a Circadian Manner in the Mouse Suprachiasmatic Nucleus.
From: Transcriptome Research Center, National Institute of Radiological Sciences, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Brain research
- Publish Date: Jul 2006
- ISSN: 0006-8993
- Volume: 1098
- Issue: 1
- Pages: 9-18
- Medium: Print
- Language: English
- Citation (JAMA): Araki Ryoko, Nakahara Maki, Fukumura Ryutaro, et al. Identification of Genes That Express in Response to Light Exposure and Express Rhythmically in a Circadian Manner in the Mouse Suprachiasmatic Nucleus.. Brain Res. Jul 2006;1098:9-18
Abstract
Most biological phenomena, including behavior and metabolic pathways, are governed by an internal clock system that is circadian (i.e., with a period of approximately 24 h) and is reset by light exposure from outside. In order to understand the molecular basis of the resetting mechanism of the clock, we attempted to isolate light-inducible transcripts in the suprachiasmatic nucleus, where the master clock resides, using a new gene expression profiling procedure. We identified 87 such transcripts, successfully cloned 60 of them and confirmed their light inducibility. Six of the 60 were already known to be light inducible and 17 are protein-coding transcripts registered in the public database that were not known to be light inducible. Induction is subjective night specific in most of the transcripts. Interestingly, 6 of the transcripts exhibit rhythmic expression in a circadian manner in the suprachiasmatic nucleus.
Mesh Headings (Keywords): Animals, Circadian Rhythm, Cloning, Molecular, Gene Expression Regulation, In Situ Hybridization, Light, Male, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins, RNA, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Suprachiasmatic Nucleus
Check for Full Text / PubMed Unique Identifier (PMID): 16780815
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