Iptakalim Alleviated the Increase of Extracellular Dopamine and Glutamate Induced by 1-methyl-4-phenylpyridinium Ion in Rat Striatum.
From: Laboratory of Neuropharmacology, Department of Anatomy, Histology & Pharmacology, Nanjing Medical University, Jiangsu, China.
Neuroscience letters
- Publish Date: Aug 2006
- ISSN: 0304-3940
- Volume: 404
- Issue: 1-2
- Pages: 187-90
- Medium: Print
- Language: English
- Citation (JAMA): Yang Yan-Jing, Wang Qing-Min, Hu Li-Fang, et al. Iptakalim Alleviated the Increase of Extracellular Dopamine and Glutamate Induced by 1-methyl-4-phenylpyridinium Ion in Rat Striatum.. Neurosci. Lett. Aug 2006;404:187-90
Abstract
The present study examined the effect of iptakalim (Ipt), a novel ATP-sensitive potassium (K(ATP)) channel opener (KCO), on 1-methyl-4-phenylpyridinium ion (MPP(+))-induced dopamine (DA) and glutamate efflux in extracellular fluid of rat striatum, using microdialysis technique. Rats were implanted guide cannula in the striatum and artificial cerebrospinal fluid was infused through a microdialysis probe to detect the level of DA and glutamate in the striatum. MPP(+) significantly enhanced the extracellular levels of DA and its metabolites, DOPAC and HVA, as well as glutamate. Application of Ipt (1, 10, 100 microM) concentration-dependently suppressed DA and its metabolites efflux induced by MPP(+). Concomitantly, Ipt reduced the increase of extracellular glutamate induced by MPP(+). These results suggest that Ipt can regulate DA and glutamate efflux induced by MPP(+) in rat striatum.
Mesh Headings (Keywords): 1-Methyl-4-phenylpyridinium, Animals, Corpus Striatum, Dopamine, Extracellular Space, Glutamic Acid, Kinetics, Male, Propylamines, Rats, Rats, Sprague-Dawley
Check for Full Text / PubMed Unique Identifier (PMID): 16781057
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