Neurons in the Guinea Pig (Cavia Porcellus) Lateral Lumbosacral Spinal Cord Project to the Central Part of the Lateral Periaqueductal Gray Matter.
From: Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Building 3215, Room 721, Antonius Deusinglaan 1, PO Box 196, 9713 AV Groningen, The Netherlands. r.kuipers@med.umcg.nl
Brain research
- Publish Date: Jul 2006
- ISSN: 0006-8993
- Volume: 1101
- Issue: 1
- Pages: 43-50
- Medium: Print
- Language: English
- Citation (JAMA): Kuipers Rutger, Klop Esther Marije, et al. Neurons in the Guinea Pig (Cavia Porcellus) Lateral Lumbosacral Spinal Cord Project to the Central Part of the Lateral Periaqueductal Gray Matter.. Brain Res. Jul 2006;1101:43-50
Abstract
In order to micturate successfully, information from the bladder has to be conveyed to the brainstem. In most experimental animals, this information is relayed, via the lumbosacral spinal cord, to the periaqueductal gray matter (PAG). Although the rat is the most used experimental animal in neurourological research, urodynamic studies show that guinea pig may be a better small experimental animal because its urodynamic profile is, in contrast to that of a rat, similar to that of humans. Therefore, the present study, using anterograde and retrograde tracing, was performed to determine whether the lumbosacral spinal cord projects to the PAG in guinea pig. Results show that neurons in the lateral part of the lumbosacral spinal cord project to the central parts of the PAG. This pathway may convey information about the level of bladder filling to the PAG.
Mesh Headings (Keywords): Animals, Brain Mapping, Guinea Pigs, Lumbosacral Region, Neural Pathways, Neurons, Periaqueductal Gray, Spinal Cord, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Check for Full Text / PubMed Unique Identifier (PMID): 16782073
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