Direct and Indirect Allorecognition.
From: Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College Hammersmith Campus, London, England.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2006
- ISSN: 1064-3745
- Volume: 333
- Issue:
- Pages: 145-56
- Medium: Print
- Language: English
- Citation (JAMA): Hornick Philip, et al. Direct and Indirect Allorecognition.. Methods Mol. Biol. 2006;333:145-56
Abstract
The design and effectiveness of strategies to promote long-term graft acceptance requires a fundamental understanding of the mechanisms underlying acute and chronic rejection. This chapter discusses the two pathways of allorecognition — direct and indirect — and suggests that the direct pathway plays a major role in the early weeks after transplantation and that the indirect pathway may contribute to the process of chronic rejection. The results of in vitro and in vivo experimental models are discussed, together with clinical data.
Mesh Headings (Keywords): Animals, Antigen Presentation, Cytotoxicity, Immunologic, Dendritic Cells, Graft Rejection, Histocompatibility Antigens, Humans, Immune Tolerance, Immunosuppression, Isoantigens, Models, Immunological, T-Lymphocyte Subsets, Transplantation Immunology
Check for Full Text / PubMed Unique Identifier (PMID): 16790850
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