Experimental Models of Graft Arteriosclerosis.
From: Cardiothoracic Surgery, National Heart and Lung Institute, London, England.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2006
- ISSN: 1064-3745
- Volume: 333
- Issue:
- Pages: 401-24
- Medium: Print
- Language: English
- Citation (JAMA): Soleimani Behzad, Shi Victor C, et al. Experimental Models of Graft Arteriosclerosis.. Methods Mol. Biol. 2006;333:401-24
Abstract
Graft arteriosclerosis (GA) is the leading cause of mortality in long-term survivors of solid organ transplantation. Although clinical studies have suggested a multifactorial etiology, the precise mechanism of disease remains obscure. Many animal models have been developed that manifest lesions resembling those of human arteriosclerosis. These models have helped us address specific mechanistic and interventional issues but, for reasons that will be discussed, have failed to assign a unitary pathogenic mechanism to clinical GA. In this chapter we describe the commonly available experimental models of GA. We further discuss the merits and limitations of each model and outline their contribution to our understanding of the pathogenesis of the disease.
Mesh Headings (Keywords): Animals, Arteriosclerosis, Graft Rejection, Models, Theoretical, Transplantation
Check for Full Text / PubMed Unique Identifier (PMID): 16790861
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