Chronic Central Nervous System Hyperinsulinemia and Regulation of Arterial Pressure and Food Intake.
From: Department of Physiology and Biophysics, and Center of Excellence in Cardiovascular Renal Research, The University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA.
Journal of hypertension
- Publish Date: Jul 2006
- ISSN: 0263-6352
- Volume: 24
- Issue: 7
- Pages: 1391-5
- Medium: Print
- Language: English
- Citation (JAMA): Liu Jiankang, da Silva Alexandre A, Tallam Lakshmi S, et al. Chronic Central Nervous System Hyperinsulinemia and Regulation of Arterial Pressure and Food Intake.. J. Hypertens. Jul 2006;24:1391-5
Abstract
BACKGROUND AND OBJECTIVE: Acute studies suggest that insulin has anorexic and hypertensive actions through direct effects on the central nervous system (CNS). However, the importance of these actions in the long-term regulation of food intake and cardiovascular function is still unclear. The goal of the present study was to determine whether chronic increases in CNS levels of insulin, in the absence of changes in plasma insulin concentration, decrease food intake and raise arterial pressure in rats. METHODS: An intracerebroventricular cannula was placed in the lateral ventricle of male Sprague-Dawley rats for chronic insulin or vehicle (artificial cerebrospinal fluid, 0.5 mul/h) infusion, via osmotic minipump, and arterial and venous catheters were implanted for measurement of mean arterial pressure (MAP) and heart rate (HR) 24 h/day and intravenous infusions. After 4 days of control measurements, insulin (6 mU/h, n = 7 or 12 mU/h, n = 6) or vehicle (n = 4) was infused intracerebroventricularly for 7 days. RESULTS: Insulin infusion at 6 or 12 mU/h caused transient decreases in food intake, but did not significantly alter plasma glucose or insulin concentrations. Insulin intracerebroventricular infusion also did not alter MAP or HR (106 +/- 2 and 105 +/- 5 versus 104 +/- 2 mmHg in control; 411 +/- 9 and 407 +/- 9 versus 410 +/- 7 bpm in control, respectively). Food intake, MAP and HR remained unchanged in the vehicle-treated group. CONCLUSIONS: These findings provide no evidence that insulin plays a major role in the long-term regulation of appetite, arterial pressure or HR. However, the CNS actions of insulin may exert modest acute effects on appetite that could play a role in limiting meal size and influencing caloric balance.
Mesh Headings (Keywords): Animals, Blood Pressure, Brain, Eating, Heart Rate, Hyperinsulinism, Hypoglycemic Agents, Insulin, Kidney, Male, Rats, Rats, Sprague-Dawley
Check for Full Text / PubMed Unique Identifier (PMID): 16794489
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.