Effects of Electroconvulsive Seizures on Na(+),k(+)-atpase Activity in the Rat Hippocampus.
From: Laboratório de Bioquímica Experimental, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil. emilio@unesc.net
Neuroscience letters
- Publish Date: Sep 2006
- ISSN: 0304-3940
- Volume: 404
- Issue: 3
- Pages: 254-7
- Medium: Print
- Language: English
- Citation (JAMA): Streck Emilio L, Feier Gustavo, Búrigo Márcio, et al. Effects of Electroconvulsive Seizures on Na(+),k(+)-atpase Activity in the Rat Hippocampus.. Neurosci. Lett. Sep 2006;404:254-7
Abstract
Although several advances have occurred concerning the use of electroconvulsive therapy, little progress has been made in understanding the mechanisms underlying its therapeutic or side effects. Na(+),K(+)-ATPase is an important enzyme of central nervous system, responsible for ionic gradient maintenance and consumption of approximately 40-50% of brain ATP. This work was performed in order to determine Na(+),K(+)-ATPase activity after acute and chronic electroconvulsive shock. Results showed an inhibition of Na(+),K(+)-ATPase activity in the hippocampus 48 h, 7, 30, 60 and 90 days after a single electroconvulsive shock. Chronic treatment diminished the enzyme activity in the hippocampus 7 and 30 days after electroconvulsive (ECS) sessions. Our findings demonstrated that Na(+),K(+)-ATPase activity is altered by ECS.
Mesh Headings (Keywords): Animals, Electroconvulsive Therapy, Hippocampus, Male, Rats, Rats, Wistar, Sodium-Potassium-Exchanging ATPase
Check for Full Text / PubMed Unique Identifier (PMID): 16797841
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