Cell-cell Interaction in the Transcellular Biosynthesis of Novel Omega-3-derived Lipid Mediators.
From: Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2006
- ISSN: 1064-3745
- Volume: 341
- Issue:
- Pages: 227-50
- Medium: Print
- Language: English
- Citation (JAMA): Chiang Nan, Serhan Charles N, et al. Cell-cell Interaction in the Transcellular Biosynthesis of Novel Omega-3-derived Lipid Mediators.. Methods Mol. Biol. 2006;341:227-50
Abstract
Omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) display beneficial actions in human diseases. The molecular basis for these actions remains of interest. We recently identified novel mediators generated from omega-3 PUFA during cell-cell interactions that displayed potent anti-inflammatory and proresolving actions. Compounds derived from EPA are designated resolvins of the E series (RvE1), and those biosynthesized from DHA are denoted resolvins of the D series (RvD) and docosatriene, such as protectin D1 (PD1), which belongs to the family of protectins. In addition, treatment using aspirin initiates a related epimeric series by triggering endogenous formation of the 17R-RvD series, denoted as aspirin-triggered (AT)-RvDs. These compounds possess potent anti-inflammatory actions in vivo that essentially are equivalent to their counterpart generated without aspirin, namely the 17S-RvDs. In this chapter, we provide an overview and detail protocols of the biosynthesis and bioactions of these newly uncovered pathways and products that include three distinct series: 18R-resolvins of the E series derived from EPA (i.e., RvE1); 17R-resolvins of the D series from DHA (AT-RvD1 through RvD4); and 17S-resolvins of the D series from DHA (RvD1 through RvD4).
Mesh Headings (Keywords): Animals, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Cell Line, Tumor, Docosahexaenoic Acids, Eicosapentaenoic Acid, Humans, Inflammation
Check for Full Text / PubMed Unique Identifier (PMID): 16799203
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