Enzymatic Activation of Voltage-gated Potassium Channels.
From: Department of Physiology, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA.
Nature
- Publish Date: Aug 2006
- ISSN: 1476-4687
- Volume: 442
- Issue: 7103
- Pages: 696-9
- Medium: Internet
- Language: English
- Citation (JAMA): Ramu Yajamana, Xu Yanping, Lu Zhe, et al. Enzymatic Activation of Voltage-gated Potassium Channels.. Nature Aug 2006;442:696-9
Abstract
Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K+ (Kv) channels by a sphingomyelinase.
Mesh Headings (Keywords): Animals, Histidine, Hydrogen-Ion Concentration, Ion Channel Gating, Kinetics, Magnesium, Membrane Potentials, Mutation, Phosphoric Diester Hydrolases, Potassium Channels, Voltage-Gated, Shab Potassium Channels, Spider Venoms
Check for Full Text / PubMed Unique Identifier (PMID): 16799569
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