Inositol 1,4,5-trisphosphate Ip(3) Receptors and Their Role in Neuronal Cell Function.
From: The Institute of Medical Science, The University of Tokyo, RIKEN, Brain Science Institute, Calcium Oscillation Project, SORST, JST, Tokyo, Japan. mikosiba@ims.u-tokyo.ac.jp
Journal of neurochemistry
- Publish Date: Jun 2006
- ISSN: 0022-3042
- Volume: 97
- Issue: 6
- Pages: 1627-33
- Medium: Print
- Language: English
- Citation (JAMA): Mikoshiba Katsuhiko, et al. Inositol 1,4,5-trisphosphate Ip(3) Receptors and Their Role in Neuronal Cell Function.. J. Neurochem. Jun 2006;97:1627-33
Abstract
Inositol 1,4,5-trisphosphate (IP(3)) receptor is a Ca(2+) release channel localized on the endoplasmic reticulum (ER) and plays an important role in neuronal function. IP(3) receptor was discovered as a developmentally regulated protein missing in the cerebellar mutant mice. Recent studies indicate that IP(3)Rs are involved in early development and neuronal plasticity. IP(3) works to release IRBIT from the IP(3) binding core in addition to release Ca(2+). IRBIT binds to and activates Na, Bicarbonate cotransporter. Electron microscopic study show the IP(3) receptor has allosteric property to change its form from square to windmill in the presence of Ca(2+). IP(3)R associates with ERp44, a redox sensor, Homer, other proteins and is transported as vesicular ER on microtubules. All these data suggests IP(3) receptor/CA(2+) channel works as a signaling center inside cells.
Mesh Headings (Keywords): Animals, Calcium, Calcium Channels, Inositol 1,4,5-Trisphosphate Receptors, Models, Biological, Models, Molecular, Neurons, Protein Binding, Receptors, Cytoplasmic and Nuclear
Check for Full Text / PubMed Unique Identifier (PMID): 16805773
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.