Efficacy of Continuous Glucose Monitoring System (Cgms) to Detect Postprandial Hyperglycemia and Unrecognized Hypoglycemia in Type 1 Diabetic Patients.
From: Department of Physiology, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. fredfrmhotmail.com
Diabetes research and clinical practice
- Publish Date: Jan 2007
- ISSN: 0168-8227
- Volume: 75
- Issue: 1
- Pages: 30-4
- Medium: Print
- Language: English
- Citation (JAMA): Maia Frederico F R, Araújo Levimar R, et al. Efficacy of Continuous Glucose Monitoring System (Cgms) to Detect Postprandial Hyperglycemia and Unrecognized Hypoglycemia in Type 1 Diabetic Patients.. Diabetes Res. Clin. Pract. Jan 2007;75:30-4
Abstract
BACKGROUND: To evaluate the efficacy of continuous glucose monitoring system (CGMS) to detect postprandial hyperglycemia and unrecognized hypoglycemia in type 1 diabetes mellitus (DM1) patients. METHODS: We studied 46 patients (43.4%M/56.6%F), average age of 25.9+/-12.8 years, submitted to 72 h CGMS. It were analyzed: capillary glycemia (CG) and CGMS sensor’s value, glycemic excursions, postprandial hyperglycemia, asymptomatic hypoglycemia and therapeutic management after CGMS. Correlation coefficient during hypo and hyperglycemia and sensitivity/specificity were determined. RESULTS: The mean capillary glucose values were 191.8+/-46.2mg/dl versus 190.9+/-42.1mg/dl by CGMS sensor, with no statistical difference by T-test (T=-0.6; p=0.79). The CGMS was significantly more efficient in detection of glycemic excursion than CG (p=0.001). The postprandial hyperglycemia was identified in 76.9% of diabetic patients and asymptomatic hypoglycemia was detected in 58.2% of these patients. The correlation coefficient presented no significance (p=0.16) during hypoglycemia versus during hyperglycemia (p=0.002). The CGMS sensor presented low sensitivity (79.1%) to detect hypoglycemia versus hyperglycemia (96.8%). CONCLUSIONS: The CGMS showed to be a good method to identify postprandial hyperglycemia, to improve therapeutics management and confirmed the low sensitivity of CGMS to detect unrecognized hypoglycemia in DM1 patients.
Mesh Headings (Keywords): Adolescent, Adult, Blood Glucose, Child, Diabetes Mellitus, Type 1, Female, Humans, Hyperglycemia, Hypoglycemia, Male, Monitoring, Ambulatory, Postprandial Period
Check for Full Text / PubMed Unique Identifier (PMID): 16806560
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