Bcl11b Participates in the Activation of Il2 Gene Expression in Cd4+ T Lymphocytes.
From: Center for Cell Biology and Cancer Research (MC-165), Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
Blood
- Publish Date: Oct 2006
- ISSN: 0006-4971
- Volume: 108
- Issue: 8
- Pages: 2695-702
- Medium: Print
- Language: English
- Citation (JAMA): Cismasiu Valeriu B, Ghanta Sailaja, Duque Javier, et al. Bcl11b Participates in the Activation of Il2 Gene Expression in Cd4+ T Lymphocytes.. Blood Oct 2006;108:2695-702
Abstract
BCL11A and BCL11B are transcriptional regulators important for lymphopoiesis and previously associated with hematopoietic malignancies. Ablation of the mouse Bcl11b locus results in failure to generate double-positive thymocytes, implicating a critical role of Bcl11b in T-cell development. However, BCL11B is also expressed in CD4+ T lymphocytes, both in resting and activated states. Here we show both in transformed and primary CD4+ T cells that BCL11B participates in the control of the interleukin-2 (IL2) gene expression following activation through T-cell receptor (TCR). BCL11B augments expression from the IL2 promoter through direct binding to the US1 site. In addition, BCL11B associates with the p300 coactivator in CD4+ T cells activated through TCR, which may account for its transcriptional activation function. These results provide the first evidence that BCL11B, originally described as a transcriptional repressor, activates transcription of a target gene in the context of T-cell activation.
Mesh Headings (Keywords): Animals, Base Sequence, Binding Sites, CD4-Positive T-Lymphocytes, Cells, Cultured, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interleukin-2, Jurkat Cells, Lymphocyte Activation, Mice, Molecular Sequence Data, Promoter Regions (Genetics), RNA, Small Interfering, Receptors, Antigen, T-Cell, Recombinant Proteins, Repressor Proteins, Transduction, Genetic, Tumor Suppressor Proteins, p300-CBP Transcription Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16809611
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