Asymmetric and Symmetric Stem-cell Divisions in Development and Cancer.
From: Howard Hughes Medical Institute and Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109-2216, USA. seanjm@umich.edu
Nature
- Publish Date: Jun 2006
- ISSN: 1476-4687
- Volume: 441
- Issue: 7097
- Pages: 1068-74
- Medium: Internet
- Language: English
- Citation (JAMA): Morrison Sean J, Kimble Judith, et al. Asymmetric and Symmetric Stem-cell Divisions in Development and Cancer.. Nature Jun 2006;441:1068-74
Abstract
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many stem cells can divide symmetrically, particularly when they are expanding in number during development or after injury. Thus, asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity.
Mesh Headings (Keywords): Animals, Cell Division, Cell Size, Neoplasms, Neoplastic Stem Cells, Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16810241
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