A Role for Corticotropin-releasing Factor in the Long-term Expression of Behavioral Sensitization to Cocaine.
From: Centre for the Neurobiology of Stress, Departments of Life Science and Psychology, University of Toronto at Scarborough, Toronto, Ontario, Canada. erb@utsc.utoronto.ca
Behavioural brain research
- Publish Date: Sep 2006
- ISSN: 0166-4328
- Volume: 172
- Issue: 2
- Pages: 360-4
- Medium: Print
- Language: English
- Citation (JAMA): Erb Suzanne, Brown Zenya J, et al. A Role for Corticotropin-releasing Factor in the Long-term Expression of Behavioral Sensitization to Cocaine.. Behav. Brain Res. Sep 2006;172:360-4
Abstract
Corticotropin-releasing factor (CRF) has been implicated in a number of the behavioral and biochemical effects of cocaine. We recently reported that central injections of CRF produce a potentiated locomotor response in animals that had been given repeated injections of cocaine up to 4 weeks earlier. We now report that with as few as 1 or 3 exposures to cocaine (total of 45 mg/kg, i.p., per day), and a drug-free period of 28 days, i.c.v. injections of CRF (0.5 microg) produce augmented locomotor responses, similar to those induced by cocaine (10 mg/kg, i.p.) itself. In addition, in animals pre-exposed to cocaine for 3 days, pre-treatment with the CRF receptor antagonist, D-Phe CRF(12-41) (1 microg, i.c.v.), blocks the expression of behavioral sensitization to a cocaine challenge after a 28-day drug-free period. These results demonstrate that short-term exposure to cocaine produces a form of long-term sensitization within systems upon which CRF acts and that activation of CRF receptors is importantly involved in the expression of behavioral sensitization to cocaine.
Mesh Headings (Keywords): Animals, Behavior, Animal, Cocaine, Corticotropin-Releasing Hormone, Dopamine Uptake Inhibitors, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Motor Activity, Rats, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16822557
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