Gomisin A Improves Scopolamine-induced Memory Impairment in Mice.
From: Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, #1 Hoeki-dong, Dongdeamoon-ku, Seoul 130-701, South Korea.
European journal of pharmacology
- Publish Date: Aug 2006
- ISSN: 0014-2999
- Volume: 542
- Issue: 1-3
- Pages: 129-35
- Medium: Print
- Language: English
- Citation (JAMA): Kim Dong Hyun, Hung Tran Manh, Bae Ki Hwan, et al. Gomisin A Improves Scopolamine-induced Memory Impairment in Mice.. Eur. J. Pharmacol. Aug 2006;542:129-35
Abstract
Gomisin A is a component of the fruits of Schizandra chinesis which are widely used as a tonic in traditional Chinese medicine. In the present study, we assessed the effect of gomisin A on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of gomisin A was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Gomisin A (5 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test (P<0.05), and also improved escape latency in the Morris water maze test at 5 mg/kg (P<0.05). Moreover, in an in vitro study, gomisin A was found to inhibit acetylcholinesterase activity in a dose-dependent manner (IC50 value; 15.5 microM). These results suggest that gomisin A may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via enhancing the cholinergic nervous system.
Mesh Headings (Keywords): Acetylcholinesterase, Amnesia, Animals, Avoidance Learning, Cholinesterase Inhibitors, Cognition, Cyclooctanes, Dioxoles, Dose-Response Relationship, Drug, Drugs, Chinese Herbal, Lignans, Male, Maze Learning, Memory, Mice, Mice, Inbred ICR, Scopolamine
Check for Full Text / PubMed Unique Identifier (PMID): 16824513
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.