Maintenance of Cd8 Effector T Cells by Cd4 Helper T Cells Eradicates Growing Tumors and Promotes Long-term Tumor Immunity.
From: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, 5, Fu-Shin Street, Kweishan, Taoyuan, Taiwan. 51424@cgmh.org.tw
Vaccine
- Publish Date: Sep 2006
- ISSN: 0264-410X
- Volume: 24
- Issue: 37-39
- Pages: 6199-207
- Medium: Print
- Language: English
- Citation (JAMA): Lin Cheng-Tao, Chang Ting-Chang, Shaw Sheng-Wen, et al. Maintenance of Cd8 Effector T Cells by Cd4 Helper T Cells Eradicates Growing Tumors and Promotes Long-term Tumor Immunity.. Vaccine Sep 2006;24:6199-207
Abstract
Human papillomavirus, particularly type 16 (HPV-16), is present in more than 99% of cervical cancers, and oncogenic HPV infection is one of the most important etiologies. It is now clear that CD4(+) T cells play an important role in controlling HPV-associated lesions because immunocompromised patients have a higher frequency of HPV-associated lesions. In the current study, we characterized the significance of CD4(+) T cells in the generation of E7-specific CD8(+) T cell immune responses in mice vaccinated with SINrep5-E7/HSP70 and boosted with vac-E7/HSP70. In addition, we characterized the contribution of CD4(+) T cells to the long-term antitumor effects. We found that vaccination with CD4 depletion significantly reduced the number of E7-specific CD8(+) T cells in mice. Furthermore, CD4(+) T cells are important for the long-term anti-tumor effects generated by vaccination with SINrep5-E7/HSP70 and booster with vac-E7/HSP70. Thus, CD4 T cells clearly have an important role in successful tumor immunity and maintenance of long-term tumor antigen-specific memory responses in vaccinated mice with established tumors.
Mesh Headings (Keywords): Animals, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Female, HSP70 Heat-Shock Proteins, Human papillomavirus 16, Mice, Mice, Inbred C57BL, Neoplasms, Experimental, Oncogene Proteins, Viral, Papillomaviridae, RNA, Viral, Sindbis Virus, T-Lymphocytes, Helper-Inducer, Viral Vaccines
Check for Full Text / PubMed Unique Identifier (PMID): 16824651
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