Role of Amygdala Mapk Activation on Immobility Behavior of Forced Swim Rats.
From: Department of Nursing, Shu-Zen College of Medicine and Management, Kaohsiung County 821, Taiwan.
Behavioural brain research
- Publish Date: Oct 2006
- ISSN: 0166-4328
- Volume: 173
- Issue: 1
- Pages: 104-11
- Medium: Print
- Language: English
- Citation (JAMA): Huang Tung-Yi, Lin Chih-Hung, et al. Role of Amygdala Mapk Activation on Immobility Behavior of Forced Swim Rats.. Behav. Brain Res. Oct 2006;173:104-11
Abstract
The role of amygdala mitogen-activated protein kinase (MAPK) in rats during a forced swim test was investigated. The variation of amygdala MAPK level was studied in control rats and early-life maternally deprived rats. A forced swim test was carried out to estimate the immobility level. The data showed that the immobility time of rats that received maternal deprivation in early life was longer than that of control rats and Western blot analysis also showed that the amygdala phospho-MAPK level in maternally deprived rats was almost two times higher than in control rats. Intra-amygdala infusion of PD098059 or U0126, MEK inhibitors, suppressed immobility behavior during the forced swim test in both rats. Western blot analysis also showed that the amygdala MAPK activities in both rats infused with MEK inhibitors were also suppressed in parallel with expression of immobility behavior. The suppressed MAPK activities as well as the restoration of immobility time returned to the original level 48 h later. These results suggest that amygdala MAPK activation might play a role in the regulation of immobility behavior in rats during the forced swim test. Moreover, it could provide a hint that amygdala MAPK activation might be involved in the formation of depression-like behavior.
Mesh Headings (Keywords): Amygdala, Animals, Enzyme Activation, Immobility Response, Tonic, Male, Maternal Deprivation, Mitogen-Activated Protein Kinases, Rats, Rats, Sprague-Dawley, Signal Transduction, Stress, Psychological, Swimming
Check for Full Text / PubMed Unique Identifier (PMID): 16828176
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