Dystrophin, Its Interactions with Other Proteins, and Implications for Muscular Dystrophy.
From: Department of Physiology, 127 Service Memorial Institute, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA. ervasti@psysiology.wisc.edu
Biochimica et biophysica acta
- Publish Date: Feb 2007
- ISSN: 0006-3002
- Volume: 1772
- Issue: 2
- Pages: 108-17
- Medium: Print
- Language: English
- Citation (JAMA): Ervasti James M, et al. Dystrophin, Its Interactions with Other Proteins, and Implications for Muscular Dystrophy.. Biochim. Biophys. Acta Feb 2007;1772:108-17
Abstract
Duchenne muscular dystrophy is the most prevalent and severe form of human muscular dystrophy. Investigations into the molecular basis for Duchenne muscular dystrophy were greatly facilitated by seminal studies in the 1980s that identified the defective gene and its major protein product, dystrophin. Biochemical studies revealed its tight association with a multi-subunit complex, the so-named dystrophin-glycoprotein complex. Since its description, the dystrophin-glycoprotein complex has emerged as an important structural unit of muscle and also as a critical nexus for understanding a diverse array of muscular dystrophies arising from defects in several distinct genes. The dystrophin homologue utrophin can compensate at the cell/tissue level for dystrophin deficiency, but functions through distinct molecular mechanisms of protein-protein interaction.
Mesh Headings (Keywords): Animals, Dystrophin, Glycoproteins, Humans, Muscular Dystrophy, Duchenne, Protein Interaction Mapping
Check for Full Text / PubMed Unique Identifier (PMID): 16829057
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