Changes of Inducible Protein-10 and Regulated Upon Activation, Normal T Cell Expressed and Secreted Protein in Acute Rejection of Pancreas Transplantation in Rats.
From: Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
World journal of gastroenterology : WJG
- Publish Date: Jul 2006
- ISSN: 1007-9327
- Volume: 12
- Issue: 26
- Pages: 4156-60
- Medium: Print
- Language: English
- Citation (JAMA): Zhu Jun, Xu Ze-Kuan, Miao Yi, et al. Changes of Inducible Protein-10 and Regulated Upon Activation, Normal T Cell Expressed and Secreted Protein in Acute Rejection of Pancreas Transplantation in Rats.. World J. Gastroenterol. Jul 2006;12:4156-60
Abstract
AIM: To investigate the role of IFN-gamma inducible protein -10 (IP-10) and regulated upon activation, normal T cell expressed and secreted (RANTES) protein in acute pancreatic allograft rejection in rats. METHODS: An experimental pancreas transplantation model was established using diabetic SD rats as the recipient, induced by applying streptozocin (STZ). Pancreas transplantation was performed with a physiologic method of portal venous and enteric drainage. Rats were divided into two groups, isograft group (group A, n = 24) and allograft group (group B, n = 24) in which either healthy SD rats or Wistar rats served as donors, respectively. Twelve diabetic or healthy SD rats were used as controls. At d 1, 4, 7, and 10 post transplantation, serum IP-10 and RANTES were assessed by ELISA and their expression in the allografts was determined by immunohistochemistry. RESULTS: In group B (allograft group), the development of acute rejection was significantly correlated with increased serum concentration and tissue expression of IP-10 and RANTES, with a peak level at d 7 post transplantation. In contrast, there was no obvious change before and after transplantation in group A (isograft group). CONCLUSION: Our study suggests a possible role of IP-10 and RANTES in acute rejection and early monitoring of chemokines may be helpful in predicting the outcome of pancreas transplantation.
Mesh Headings (Keywords): Animals, Chemokine CCL5, Chemokine CXCL10, Chemokines, Chemokines, CXC, Diabetes Mellitus, Experimental, Gene Expression Regulation, Graft Rejection, Graft Survival, Male, Pancreas, Pancreas Transplantation, Rats, Rats, Sprague-Dawley, Rats, Wistar
Check for Full Text / PubMed Unique Identifier (PMID): 16830364
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