Identification of a Receptor Necessary for Nogo-b Stimulated Chemotaxis and Morphogenesis of Endothelial Cells.
From: Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Jul 2006
- ISSN: 0027-8424
- Volume: 103
- Issue: 29
- Pages: 10997-1002
- Medium: Print
- Language: English
- Citation (JAMA): Miao Robert Qing, Gao Yuan, Harrison Kenneth D, et al. Identification of a Receptor Necessary for Nogo-b Stimulated Chemotaxis and Morphogenesis of Endothelial Cells.. Proc. Natl. Acad. Sci. U.S.A. Jul 2006;103:10997-1002
Abstract
Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates vascular function is unknown. Here, we identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B and show that Nogo-B receptor localizes with the ligand Nogo-B during VEGF and wound healing angiogenesis in vivo, mediates chemotaxis in a heterologous expression system and chemotaxis, and 3D tube formation in native endothelial cells. Thus, identification of this receptor may lead to the discovery of agonists or antagonists of this pathway to regulate vascular remodeling and angiogenesis.
Mesh Headings (Keywords): Amino Acid Sequence, Animals, Cell Shape, Cells, Cultured, Cercopithecus aethiops, Chemotaxis, Cricetinae, Endothelial Cells, Humans, Mice, Molecular Sequence Data, Myelin Proteins, Protein Binding, Protein Isoforms, Receptors, Cell Surface
Check for Full Text / PubMed Unique Identifier (PMID): 16835300
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