Electrophysiological and Gene Expression Profiling of Neuronal Cell Types in Mammalian Neocortex.
From: Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.
The Journal of physiology
- Publish Date: Sep 2006
- ISSN: 0022-3751
- Volume: 575
- Issue: Pt 2
- Pages: 361-5
- Medium: Print
- Language: English
- Citation (JAMA): Yano Kojiro, Subkhankulova Tatiana, Livesey Frederick J, et al. Electrophysiological and Gene Expression Profiling of Neuronal Cell Types in Mammalian Neocortex.. J. Physiol. (Lond.) Sep 2006;575:361-5
Abstract
It is a challenging question to understand how different neuronal types are organized into a complex architecture in the cortex, an architecture which is also adapted in different regions to subserve very different functions. Recent developments in genetic and molecular techniques have opened up the possibility of using gene expression profiling for neuronal cell typing, with the aim of uncovering novel cell types and the underlying mechanisms which generate and maintain neuronal heterogeneity in the cortex. This review introduces some current ideas about neuronal cell types in the cortex and describes recent approaches to expression profiling for defining cortical neuronal cell types.
Mesh Headings (Keywords): Animals, Electrophysiology, Gene Expression Profiling, Humans, Mammals, Neocortex, Neurons, Oligonucleotide Array Sequence Analysis, Patch-Clamp Techniques
Check for Full Text / PubMed Unique Identifier (PMID): 16840515
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