A Randomized Trial of Adding Insulin Glargine Vs. Avoidance of Insulin in People with Type 2 Diabetes on Either No Oral Glucose-lowering Agents or Submaximal Doses of Metformin And/Or Sulphonylureas. The Canadian Insight (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study.
From: Division of Endocrinology and Metabolism and the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada. gerstein@mcmaster.ca
Diabetic medicine : a journal of the British Diabetic Association
- Publish Date: Jul 2006
- ISSN: 0742-3071
- Volume: 23
- Issue: 7
- Pages: 736-42
- Medium: Print
- Language: English
- Citation (JAMA): Gerstein H C, Yale J-F, Harris S B, et al. A Randomized Trial of Adding Insulin Glargine Vs. Avoidance of Insulin in People with Type 2 Diabetes on Either No Oral Glucose-lowering Agents or Submaximal Doses of Metformin And/Or Sulphonylureas. The Canadian Insight (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study.. Diabet. Med. Jul 2006;23:736-42
Abstract
AIMS: Insulin is generally withheld until people with Type 2 diabetes are unresponsive to other therapies. However, its potential advantages suggest that it could be added earlier to achieve glycaemic goals; this possibility was tested in a clinical trial. METHODS: Consenting adults aged 18-80 years with Type 2 diabetes for at least 6 months, HbA1c of 7.5-11%, and on 0, 1 or 2 oral agents, were randomized to one of two therapeutic approaches for 24 weeks: evening insulin glargine plus self-titration by 1 unit/day if the fasting plasma glucose (FPG) was > 5.5 mmol/l; or conventional therapy with physician adjustment of oral glucose-lowering agents if capillary FPG levels were > 5.5 mmol/l. The primary outcome was the first achievement of two consecutive HbA1c levels
Mesh Headings (Keywords): Adolescent, Adult, Aged, Aged, 80 and over, Blood Glucose, Canada, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, Hemoglobin A, Glycosylated, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Sulfonylurea Compounds, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 16842477
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