The Benefits of Oestrogens on Postprandial Lipid Metabolism Are Lost in Post-menopausal Women with Type 2 Diabetes.
From: Southampton University Hospitals NHS Trust, Southampton, UK. mike.masding@poole.nhs.uk
Diabetic medicine : a journal of the British Diabetic Association
- Publish Date: Jul 2006
- ISSN: 0742-3071
- Volume: 23
- Issue: 7
- Pages: 768-74
- Medium: Print
- Language: English
- Citation (JAMA): Masding M G, Stears A J, Burdge G C, et al. The Benefits of Oestrogens on Postprandial Lipid Metabolism Are Lost in Post-menopausal Women with Type 2 Diabetes.. Diabet. Med. Jul 2006;23:768-74
Abstract
AIMS: Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non-diabetic and diabetic post-menopausal women. METHODS: In a cross-sectional study, fasting subjects [HRT+ and HRT- control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT-n = 14, control HRT+n = 7, control HRT-n = 11] consumed a meal containing the stable isotope 1,1,1-[13]C-tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period. RESULTS: In diabetic women, there were no differences between the HRT+ and HRT- groups for any of these parameters. In contrast, in HRT+ compared with HRT- control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT- 9.7 (3.9, 18.5) mmol/l per 6 h, P < 0.05] and [13]C-palmitic acid in the TG fraction was also lower [HRT+ 23.2 (10.3, 41.3) ng/ml per 6 h, HRT- 47.7 (12.6, 77.2) ng/ml per 6 h, P < 0.05], suggesting the lower postprandial triglyceridaemia associated with HRT in non-diabetic women is because of better chylomicron clearance. CONCLUSIONS: The oestrogen-associated advantage in clearance of dietary lipid we observed in non-diabetic post-menopausal women is not seen in post-menopausal diabetic women. This is likely to promote an atherogenic lipoprotein profile and may contribute to the loss of CVD protection seen in diabetic women.
Mesh Headings (Keywords): Blood Glucose, Cholesterol, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Estrogen Replacement Therapy, Estrogens, Fatty Acids, Nonesterified, Female, Humans, Insulin, Lipoproteins, HDL, Middle Aged, Palmitic Acid, Postmenopause, Postprandial Period, Triglycerides
Check for Full Text / PubMed Unique Identifier (PMID): 16842482
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.