Derivation and Characterization of Hepatocytes from Embryonic Stem Cells in Vitro.
From: Program in Tissue Engineering, Department of Parasitology, Nara Medical University, Japan.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2006
- ISSN: 1064-3745
- Volume: 330
- Issue:
- Pages: 387-99
- Medium: Print
- Language: English
- Citation (JAMA): Ishizaka Shigeaki, Ouji Yukiteru, Yoshikawa Masahide, et al. Derivation and Characterization of Hepatocytes from Embryonic Stem Cells in Vitro.. Methods Mol. Biol. 2006;330:387-99
Abstract
From a therapeutic perspective on liver, the use of embryonic stem (ES) technology in the generation of a large number of high-functional hepatocytes developed from ES cells for cell transplantation is anticipated. We have explored a three-dimensional culture system in which hepatocytes differentiated from mouse ES cells by transfection with the hepatocyte nuclear factor-3beta possess high metabolic functions that can be maintained long term.
Mesh Headings (Keywords): Animals, Biological Markers, Cell Culture Techniques, Cell Differentiation, Cells, Cultured, Embryo, Mammalian, Hepatocytes, Mice, Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16846038
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