Discriminative-stimulus Effects of Methamphetamine and Morphine in Rats Are Attenuated by Camp-related Compounds.
From: Department of Neuropsychopharmacology & Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Behavioural brain research
- Publish Date: Oct 2006
- ISSN: 0166-4328
- Volume: 173
- Issue: 1
- Pages: 39-46
- Medium: Print
- Language: English
- Citation (JAMA): Yan Yijin, Nitta Atsumi, Mizuno Tomoko, et al. Discriminative-stimulus Effects of Methamphetamine and Morphine in Rats Are Attenuated by Camp-related Compounds.. Behav. Brain Res. Oct 2006;173:39-46
Abstract
Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been reported to modulate cAMP level in vivo, on the discriminative-stimulus effects of methamphetamine (METH) and morphine in rats. All these compounds inhibited the discriminative-stimulus effects of METH, while only rolipram and nefiracetam attenuated the discriminative-stimulus effects of morphine. In addition, neither nifedipine nor neomycin, two voltage-sensitive calcium channel blockers, was found to modulate the effect of nefiracetam on METH-associated discriminative stimuli, suggesting that the inhibitory effect of nefiracetam may not involve the activation of calcium channels. These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse.
Mesh Headings (Keywords): Analysis of Variance, Animals, Calcium Channel Blockers, Central Nervous System Agents, Central Nervous System Stimulants, Cyclic AMP, Discrimination Learning, Dopamine Antagonists, Male, Methamphetamine, Morphine, Narcotics, Pyrrolidinones, Rats, Rats, Sprague-Dawley, Receptors, Dopamine D2, Rolipram, Second Messenger Systems, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 16857277
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