Effect of a Short-acting No Donor on Bubble Formation from a Saturation Dive in Pigs.
From: Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrres gt. 3, N-7489 Trondheim, Norway. andreas.mollerlokken@ntnu.no
Journal of applied physiology (Bethesda, Md. : 1985)
- Publish Date: Dec 2006
- ISSN: 8750-7587
- Volume: 101
- Issue: 6
- Pages: 1541-5
- Medium: Print
- Language: English
- Citation (JAMA): Møllerløkken A, Berge V J, Jørgensen A, et al. Effect of a Short-acting No Donor on Bubble Formation from a Saturation Dive in Pigs.. J. Appl. Physiol. Dec 2006;101:1541-5
Abstract
It has previously been reported that a nitric oxide (NO) donor reduces bubble formation from an air dive and that blocking NO production increases bubble formation. The present study was initiated to see whether a short-acting NO donor (glycerol trinitrate, 5 mg/ml; Nycomed Pharma) given immediately before start of decompression would affect the amount of vascular bubbles during and after decompression from a saturation dive in pigs. A total of 14 pigs (Sus scrofa domestica of the strain Norsk landsvin) were randomly divided into an experimental (n = 7) and a control group (n = 7). The pigs were anesthetized with ketamine and alpha-chloralose and compressed in a hyperbaric chamber to 500 kPa (40 m of seawater) in 2 min, and they had 3-h bottom time while breathing nitrox (35 kPa O(2)). The pigs were all decompressed to the surface (100 kPa) at a rate of 200 kPa/h. During decompression, the inspired Po(2) of the breathing gas was kept at 100 kPa. Thirty minutes before decompression, the experimental group received a short-acting NO donor intravenously, while the control group were given equal amounts of saline. The average number of bubbles seen during the observation period decreased from 0.2 to 0.02 bubbles/cm(2) (P < 0.0001) in the experimental group compared with the controls. The present study gives further support to the role of NO in preventing vascular bubble formation after decompression.
Mesh Headings (Keywords): Animals, Decompression Sickness, Diving, Embolism, Air, Heart, Male, Myocardium, Nitric Oxide Donors, Oxidoreductases, Oxygen, Swine, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 16857861
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