Role of Calcified Spots Detected by Intravascular Ultrasound in Patients with St-segment Elevation Acute Myocardial Infarction.
From: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
The American journal of cardiology
- Publish Date: Aug 2006
- ISSN: 0002-9149
- Volume: 98
- Issue: 3
- Pages: 309-13
- Medium: Print
- Language: English
- Citation (JAMA): van der Hoeven Barend L, Liem Su-San, Oemrawsingh Pranobe V, et al. Role of Calcified Spots Detected by Intravascular Ultrasound in Patients with St-segment Elevation Acute Myocardial Infarction.. Am. J. Cardiol. Aug 2006;98:309-13
Abstract
Electron beam computed tomographic studies have demonstrated that the extent of intracoronary calcium is related to risk of coronary events. This study was performed to gain further insight into the distribution of focal calcifications and their relation to the site of plaque rupture within the culprit artery in consecutive patients (n = 60) with acute myocardial infarction (AMI) using intravascular ultrasound imaging. Calcifications in the culprit lesion and adjacent segments were classified and counted according to their arc (< 45 degrees, 45 degrees to 90 degrees, 90 degrees to 180 degrees, > 180 degrees), length (< 1.5, 1.5 to 3.0, 3.0 to 6.0, > 6.0 mm), and dispersion (number of spots per millimeter). Calcifications at the edge of a visible rupture or ulceration were considered related to the AMI. Compared with adjacent proximal and distal segments, the culprit lesion contained more calcified spots per millimeter (0.14, 0.10, and 0.21, respectively, p < 0.05). Small calcified spots (arc < 45 degrees, length < 1.5 mm) were more common (p < 0.05). Plaque rupture or ulceration was manifest in 31 culprit lesions (52%), 14 (45%) of which contained focal calcifications. These calcified spots extended more often to 90 degrees to 180 degrees of the vessel circumference and were more often of moderate length (3 to 6 mm) compared with culprit lesions without visible plaque rupture (p < 0.05). In conclusion, culprit lesions in patients with AMI contain more and smaller calcifications compared with adjacent segments. Calcifications related to plaque rupture appear to be larger and extend over a wider arc compared with these calcified spots. Those larger calcified spots may play a role in plaque instability in a subgroup of lesions.
Mesh Headings (Keywords): Calcinosis, Coronary Vessels, Disease Progression, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Prognosis, Retrospective Studies, Risk Factors, Severity of Illness Index, Ultrasonography, Interventional
Check for Full Text / PubMed Unique Identifier (PMID): 16860014
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.