Murine Model of Infection by Tropheryma Whipplei.
From: Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, 27 Bld. Jean Moulin, 13385 Marseille Cedex 05, France.
Infection and immunity
- Publish Date: Aug 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 8
- Pages: 4915-7
- Medium: Print
- Language: English
- Citation (JAMA): Genot Séverine, Stein Andreas, Lepidi Hubert, et al. Murine Model of Infection by Tropheryma Whipplei.. Infect. Immun. Aug 2006;74:4915-7
Abstract
We developed an animal model reproducing several aspects of Whipple’s disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.
Mesh Headings (Keywords): Actinomycetales, Actinomycetales Infections, Animals, Disease Models, Animal, Female, Granuloma, Liver, Mice, Mice, Inbred BALB C, Mice, SCID, Whipple Disease
Check for Full Text / PubMed Unique Identifier (PMID): 16861681
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