A Quantitative Trait Locus on Chromosome 6 Regulates the Onset of Puberty in Mice.
From: Division of Pediatric Endocrinology and Metabolism, Rainbow Babies and Children’s Hospital, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.
Endocrinology
- Publish Date: Nov 2006
- ISSN: 0013-7227
- Volume: 147
- Issue: 11
- Pages: 5132-8
- Medium: Print
- Language: English
- Citation (JAMA): Nathan Brandon M, Hodges Craig A, Supelak Pamela J, et al. A Quantitative Trait Locus on Chromosome 6 Regulates the Onset of Puberty in Mice.. Endocrinology Nov 2006;147:5132-8
Abstract
Puberty is a fundamental developmental process experienced by all reproductively competent adults, yet the specific factors that regulate variation in its timing remain elusive. Using a new approach to identifying these factors, we have performed a survey among a panel of chromosome substitution strains (for inbred strains C57BL/6J and A/J) followed by linkage analysis to map a quantitative trait locus (QTL) on the distal end of chromosome 6 that regulates pubertal timing (as assessed by vaginal opening) in mice. The location of the QTL was then refined to a region between marker D6MIT59 and the end of the chromosome by generating and phenotyping a panel of 12 congenic strains, each with a unique and overlapping homozygous segment of the A/J chromosome on an otherwise uniform C57BL/6J genomic background. Additional characterization of the QTL indicated that the effects of the responsible gene(s) are gender specific and inherited in a codominant manner without parent-of-origin effects. These findings represent an important advancement toward identification of novel factors that regulate maturation of the hypothalamic-pituitary-gonadal axis and determine the timing of puberty.
Mesh Headings (Keywords): Animals, Chromosome Mapping, Female, Linkage (Genetics), Male, Mice, Mice, Inbred C57BL, Quantitative Trait Loci, Sexual Maturation
Check for Full Text / PubMed Unique Identifier (PMID): 16873534
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.