Bafoudiosbulbins A, and B, Two Anti-salmonellal Clerodane Diterpenoids from Dioscorea Bulbifera L. Var Sativa.
From: Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Phytochemistry
- Publish Date: Sep 2006
- ISSN: 0031-9422
- Volume: 67
- Issue: 17
- Pages: 1957-63
- Medium: Print
- Language: English
- Citation (JAMA): Teponno Rémy Bertrand, Tapondjou Azefack Léon, Gatsing Donatien, et al. Bafoudiosbulbins A, and B, Two Anti-salmonellal Clerodane Diterpenoids from Dioscorea Bulbifera L. Var Sativa.. Phytochemistry Sep 2006;67:1957-63
Abstract
Two clerodane diterpenoids, Bafoudiosbulbins A 1, and B 2, together with five known compounds: tetracosanoic acid, 1-(tetracosanoyl)-glycerol, trans-tetracosanylferulate, beta-sitosterol and 3-O-beta-D-glucopyranosyl-beta-sitosterol were isolated from the tubers of Dioscorea bulbifera L. var sativa. Their structures were established by spectroscopic methods (1D and 2D-NMR, MS) and X-ray crystallographic diffraction analysis of compound 1. The CH2Cl2-soluble portion of the crude extract and the two clerodanes were screened for anti-bacterial activity using both agar diffusion and broth dilution techniques against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi A and Salmonella paratyphi B. They both showed significant activities against P. aeruginosa, S. typhi, S. paratyphi A and S. paratyphi B.
Mesh Headings (Keywords): Bacteria, Dioscorea, Diterpenes, Diterpenes, Clerodane, Fatty Acids, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Structure, Plant Extracts, Salmonella typhi, X-Ray Diffraction
Check for Full Text / PubMed Unique Identifier (PMID): 16876211
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