Central Glucagon Like Peptide-1 Delays Solid Gastric Emptying Via Central Crf and Peripheral Sympathetic Pathway in Rats.
From: Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Brain research
- Publish Date: Sep 2006
- ISSN: 0006-8993
- Volume: 1111
- Issue: 1
- Pages: 117-21
- Medium: Print
- Language: English
- Citation (JAMA): Nakade Yukiomi, Tsukamoto Kiyoshi, Pappas Theodore N, et al. Central Glucagon Like Peptide-1 Delays Solid Gastric Emptying Via Central Crf and Peripheral Sympathetic Pathway in Rats.. Brain Res. Sep 2006;1111:117-21
Abstract
It has been shown that glucagon like peptide-1 (GLP-1) acts on the central nervous system (CNS), in addition to its peripheral actions. Central administration of glucagon like peptide-1 (GLP-1) delays liquid gastric emptying via non-adrenergic, non-cholinergic neurons in rats. However, it remains unclear how central GLP-1 delays solid gastric emptying in rats. GLP-1 receptors at the CNS mediates the endocrine and anxiety responses to psychogenic and interoceptive stress. Corticotropin-releasing factor (CRF) is also known as a stress-related peptide, which delays gastric emptying of liquid and solid food via the autonomic nervous system. We have recently showed that central CRF delays solid gastric emptying via sympathetic pathways in rats. However, it remains unknown how central GLP-1 and CRF interact in mediating the inhibitory effect on solid gastric emptying. After a 24 h-fasting, GLP-1 was administered by intracisternal (ic)-injection immediately after the solid meal ingestion. Ninety minutes after the peptide injection, gastric contents were measured. Ic-injection of GLP-1 (30-3000 pmol) dose-dependently inhibited solid gastric emptying. Ic-injection of GLP-1 (3000 pmol)-induced delay of gastric emptying was partially antagonized by celiac ganglionectomy but not by atropine or N(G)-nitro-l-arginine methyl ester (L-NAME). Ic-injection of a CRF antagonist, astressin (2.8 nmol), partially antagonized GLP-1-induced delay of solid gastric emptying. These results indicate that central CRF and peripheral sympathetic pathway are, at least in part, involved in mediating central GLP-1-induced delay of solid gastric emptying in rats.
Mesh Headings (Keywords): Animals, Autonomic Pathways, Central Nervous System, Cholinergic Antagonists, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Enzyme Inhibitors, Ganglia, Sympathetic, Glucagon-Like Peptide 1, Male, Neuroprotective Agents, Peptide Fragments, Peristalsis, Rats, Rats, Sprague-Dawley, Stomach, Sympathetic Nervous System, Vagotomy
Check for Full Text / PubMed Unique Identifier (PMID): 16884700
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