What's in a Name? Enos and Anaphylactic Shock.
From: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
The Journal of clinical investigation
- Publish Date: Aug 2006
- ISSN: 0021-9738
- Volume: 116
- Issue: 8
- Pages: 2075-8
- Medium: Print
- Language: English
- Citation (JAMA): Lowenstein Charles J, Michel Thomas, et al. What's in a Name? Enos and Anaphylactic Shock.. J. Clin. Invest. Aug 2006;116:2075-8
Abstract
In this issue of the JCI, a study by Cauwels and colleagues suggests a central role for eNOS, the endothelial isoform of nitric oxide synthase, as a mediator of anaphylaxis (see the related article beginning on page 2244). Why is an enzyme originally described as a physiological mediator of vascular homeostasis implicated in the spectacular vascular collapse that is characteristic of anaphylaxis? And is the eNOS involved in anaphylaxis necessarily exerting its effect solely in the vascular endothelium, or might this “endothelial enzyme” actually be playing a more fundamental role in an entirely different tissue? After all, what’s in a name?
Mesh Headings (Keywords): Anaphylaxis, Animals, Brain, Disease Models, Animal, Humans, Mice, Models, Biological, Nitric Oxide, Nitric Oxide Synthase Type III
Check for Full Text / PubMed Unique Identifier (PMID): 16886052
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